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Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging

Decuypere, E; Riomet, M; Sallustrau, A; Bregant, S; Thai, R; Pieters, G; Clavier, G; Audisio, D; Taran, F, Chemical Communications, 2018, 24, 10758-10761.

Références :

Chemical Communications, 2018, 24, 10758-10761.

Auteur(s) : 
Decuypere, E; Riomet, M; Sallustrau, A; Bregant, S; Thai, R; Pieters, G; Clavier, G; Audisio, D; Taran, F

Copper-catalyzed and copper-free sydnone–alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in bioorthogonal labeling is still in its infancy. Herein, combinations of alkynes and coumarin-sydnones were screened for their ability to generate pyrazole products displaying strong fluoroscence enhancement compared to reactants. One sydnone was identified as a particularly suitable new turn-on probe for protein labeling.

graphical abstract
Type :
Publication
Dates :
Paru le 28 septembre 2018
Informations complémentaires :
DOI: 10.1039/c8cc06070c

 

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