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Accueil > Recherche > Publications / brevets > Publications équipe SMALL > Synthèse valo biomolécules

Construction of triazolyl bidentate glycoligands (TBGs) by grafting of 3-azidocoumarin to epimeric pyranoglycosides via a fluorogenic dual click reaction

J. L. Xue, X. P. He, J. W. Yang, D. T. Shi, C. Y. Cheng, J. Xie, G. R. Chen and K. Chen Carbohydr. Res., 2012, 363, 38-42

Références :

Carbohydr. Res., 2012, 363, 38-42

Auteur(s) : 
J. L. Xue, X. P. He, J. W. Yang, D. T. Shi, C. Y. Cheng, J. Xie, G. R. Chen and K. Chen

Glycoligands, which feature a glycoside as the central template incorporating Lewis bases as metal chelation sites and various fluorophores as the chemical reporter, represent a range of interesting scaffolds for development of chemosensors. Here, new types of triazolyl bidentate glycoligands (TBGs) based on the grafting of 3-azidocoumarin to the C2,3- or C4,6-positions of three epimeric pyranoglycosides including a glucoside, a galactoside, and a mannoside were efficiently synthesized via a fluorogenic dual click reaction assisted by microwave irradiation. The desired TBGs were afforded in high conversion rates (>90%) and reasonable yields ( approximately 70%). Moreover, a preliminary optical study of two hydroxyl-free glucoside-based TBGs indicates that these compounds are strongly fluorescent in pure water, implying their potential for ion detections in aqueous media.




Type :
Publication
Dates :
Paru le 12 octobre 2012
Informations complémentaires :
doi 10.1016/j.carres.2012.10.001

 

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