Accès direct au contenu

PPSM

Version anglaise

aide

Accueil > Publications / brevets > Publications équipe SMALL > Synthèse valo biomolécules

Recherche - Valorisation

Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: Synthesis, characterization and cytotoxicity

Deo, C; Wang, H; Bogliotti, N; Zang, Y; Retailleau, P; He, XP; Li, J; Xie, J JOURNAL OF ORGANOMETALLIC CHEMISTRYT 2016, 820, 111-119.

Références :

JOURNAL OF ORGANOMETALLIC CHEMISTRYT 2016, 820, 111-119.

Auteur(s) : 

Deo, C; Wang, H; Bogliotti, N; Zang, Y; Retailleau, P; He, XP; Li, J; Xie, J

A new series of arene chlorido ruthenium and pentamethylcyclopentadienyl chlorido rhodium complexes containing o-sulfonamide azobenzene ligands with an exocyclic N=N bond coordination pattern have been synthesized. These complexes undergo readily E -> Z photoisomerization followed by thermal Z -> E isomerization (upon resting in the dark). The ruthenium complexes showed low-micromole-ranged cytotoxicity towards a panel of cancer cells. Western blotting and flow cytometric analyses suggest that 1) they are potent apoptotic inducers for cancer cells, probably through a caspase-3 dependent apoptotic pathway, and that 2) they have a much stronger ability to induce HeLa cancer cell apoptosis than cisplatin, a commercial anticancer drug.

Illustration Article Deo
Type :
Publication
Dates :
Paru le 3 août 2016
Informations complémentaires :
DOI: 10.1016/j.jorganchem.2016.07.009

Recherche d'un document

Recherche d'un document