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Synthesis and characterization of various 5-dye-labeled ribonucleosides

De Schutter, C; Roy, V; Favetta, P; Pavageau, C; Maisonneuve, S; Bogliotti, N; Xie, J; Agrofoglio, LA, Organic & Biomolecular Chemistry, 2018, 16, 6552-6563.

Hitherto unknown chromophoric nucleosides are reported. This novel set of visibly coloured dye-labeled 5′-nucleosides, including 1,2,4,5-tetrazine, dicyanomethylene-4H-pyran, benzophenoxazinone, 9,10-anthraquinone and azobenzene chromophores, were prepared mainly under Cu-catalyzed azide–alkyne cycloaddition (CuAAC). The design criteria are outlined. Several derivatives possess in supplement a fluorescence property. The absorption and fluorescence spectra of all coloured nucleosides were recorded to study their potential as visible-range probes. Such nucleodyes are of great interest for future competitive lateral flow test MIP-based strips.

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Publication

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Paru le 21 septembre 2018

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DOI: 10.1039/c8ob01606b