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Synthesis of O-Amino Sugars and Nucleosides

Chen, N; Xie, J, Molecules, 2018, 23, 641.

Références :

Molecules, 2018, 23, 641.

Auteur(s) : 
Chen, N; Xie, J

Nucleic acids and carbohydrates are essential biomolecules involved in numerous biological and pathological processes. Development of multifunctional building blocks based on nucleosides and sugars is in high demand for the generation of novel oligonucleotide mimics and glycoconjugates for biomedical applications. Recently, aminooxyl-functionalized compounds have attracted increasing research interest because of their easy derivatization through oxime ligation or N-oxyamide formation reactions. Various biological applications have been reported for O-amino carbohydrate- and nucleoside-derived compounds. Here, we report our efforts in the design and synthesis of glyco-, glycosyl, nucleoside- and nucleo-aminooxy acid derivatives from readily available sugars and amino acids, and their use for the generation of N-oxyamide-linked oligosaccharides, glycopeptides, glycolipids, oligonucleosides and nucleopeptides as novel glycoconjugates or oligonucleotide mimics. Delicate and key points in the synthesis will be emphasized.

graphical abstract
Type :
Publication
Dates :
Paru le 12 mars 2018
Informations complémentaires :
DOI: 10.3390/molecules23030641

 

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