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Accueil > Recherche > Publications / brevets > Publications équipe SMALL > Synthèse valo biomolécules

Synthesis of Thymidine Dimers from 5′-O-Aminothymidine

S. Peyrat and J. Xie Synthesis, 2012, 44, 11, 1718-1724

Références :

Synthesis, 2012, 44, 11, 1718-1724

Auteur(s) : 
S. Peyrat and J. Xie

The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N-oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O-amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N-oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5′-O-aminothymidine is reported.




Type :
Publication
Dates :
Paru le 9 mai 2012
Informations complémentaires :
doi 10.1055/s-0031-1289759

 

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