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Accueil > Recherche > Publications / brevets > Publications équipe SMALL > Synthèse valo biomolécules

6-O-Amino-2-O-carboxymethyl Glucopyranoside as Novel Glycoaminoxy Acid Building Block for the Construction of Oligosaccharide Mimetics

Z. Song, X.-P. He, G.-R. Chen and J. Xie Synthesis, 2011, 17, 2761-2766

Références :

Synthesis, 2011, 17 2761-2766

Auteur(s) : 

Z. Song, X.-P. He, G.-R. Chen and J. Xie


The synthesis of diversely functionalized carbohydrate building blocks is of great interest towards the generation of new carbohydrate mimetics. Glycoaminoxy acids are recently developed glycoamino acid analogues with both an aminoxy and a carboxyl group connected to the sugar scaffold. These molecules could be readily used for the synthesis of various glycoconjugates through N-oxy amide or oxime bond, thus providing a potent tool for the design of novel functional carbohydrate mimetics. Here, the efficient synthesis of 2,6-functionalized pyranoid glycoaminoxy acid from commercially available methyl glucopyranoside is reported. The subsequent assembly of this glycoaminoxy acid building unit via N-acylation led successfully to the novel 2,6-linked oligosaccharide mimetics.




Type :
Publication
Dates :
Paru le 28 juillet 2011
Informations complémentaires :
doi 10.1055/s-0030-1260139

 

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