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Accueil > Recherche > Publications / brevets > Publications équipe SMALL > Synthèse valo biomolécules

A 'Clicked' Tetrameric Hydroxamic Acid Glycopeptidomimetic Antagonizes Sugar-Lectin Interactions On The Cellular Level

Zhang, HL; Zang, Y; Xie, J; Li, J; Chen, GR; He, XP; Tian, H SCIENTIFIC REPORTS, 2014, 4, 5513.

Références :

SCIENTIFIC REPORTS, 2014, 4, 5513.

Auteur(s) : 

Zhang, HL; Zang, Y; Xie, J; Li, J; Chen, GR; He, XP; Tian, H

A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level.

Type :
Publication
Dates :
Paru le 1 juillet 2014
Informations complémentaires :

DOI: 10.1038/srep05513


 

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