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Accueil > Recherche > Publications / brevets > Publications équipe SMALL > Synthèse valo biomolécules

Discovering the distinct inhibitory effects between C4-epimeric glycosyl amino acids: new insight into the development of protein tyrosine phosphatase inhibitors

X. P. He, C. Li, Z. Z. Wang, L. X. Gao, X. X. Shi, Y. Tang, J. Xie, J. Li, G. R. Chen and K. X. Chen Glycoconjugate J., 2011, 28, 7, 493-497

Références :

Glycoconjugate J., 2011, 28, 7, 493-497

Auteur(s) : 

X. P. He, C. Li, Z. Z. Wang, L. X. Gao, X. X. Shi, Y. Tang, J. Xie, J. Li, G. R. Chen and K. X. Chen









There has been increasing interest in the development of drug candidates based on sugar templates that possess rich structural and, especially, configurational diversities. We disclose herein that the epimeric identity between methyl 3,4-bis-phenylalanyl/tyrosinyl triazolyl-alpha-D-galactopyranoside and glucopyranoside may lead to their distinct inhibitory effects on specific protein tyrosine phosphatases (PTPs). Subsequently performed molecular docking study elucidated the plausible binding behaviors of the more potent galactosyl inhibitors with their primary PTP target, i.e. Cell Division Cycle 25B (CDC25B) phosphatase.




Type :
Publication
Dates :
Paru le 6 septembre 2011
Informations complémentaires :
doi 10.1007/s10719-011-9347-0

 

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