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Horaires à
Lieu Amphi Dorothy Hodgkin
Jérôme Lacour est professeur au Département de chimie organique de l'Université de Genève (Suisse).
Résumé (en anglais)
Charged molecules and intermediates display unique reactivity and properties. In this context, studies on original cationic [4] and [6]helicenes will be presented. These compounds display original chemical and electronic properties thanks to the extended delocalization provided by the triarylcarbenium framework.[1] Molecular engineering towards novel reactivities and properties, electronic and chiroptical in particular, will be reported.[2]
Also, a focus will be given on metal-catalyzed decompositions of -diazocarbonyls – and those involving CpRu complexes [3] particular. An attention will be given to routes affording ylide intermediates and then functionally rich heterocyclic derivatives. A large variety of stereoselective and enantiospecific transformations are available through these metal carbene reactions and subsequent ylide transformations. Mechanistic investigations will be detailed during the lecture.
References
[1] J. Bosson, N. Bisballe, B. W. Laursen, J. Lacour, in Helicenes. Synthesis, Properties and Applications (Eds.: J. Crassous, I. G. Stara, I. Stary), Wiley-VCH, 2022, pp. 127-165.
[2] a) B. Fabri, D. F. De Rosa, D. J. Black, R. Mucci, A. Krimovs, R. Pal, J. Lacour, Chem. Eur. J. 2025, 31, e202501212; b) S. G. Stenspil, A. H. Olsson, R. Mucci, M. Pink, C. Besnard, G. Pescitelli, J. Lacour, A. H. Flood, B. W. Laursen, Angew .Chem. Int. Ed. 2024, e202412320; c) B. Fabri, T. Funaioli, L. Frédéric, C. Elsner, E. Bordignon, F. Zinna, L. Di Bari, G. Pescitelli, J. Lacour, J. Am. Chem. Soc. 2024, 146, 8308–8319; d) R. Tarrieu, I. Hernández Delgado, F. Zinna, V. Dorcet, S. Colombel-Rouen, C. Crévisy, O. Baslé, J. Bosson, J. Lacour, Chem. Commun. 2021, 75, 3793-3796; e) J. Bosson, G. M. Labrador, C. Besnard, D. Jacquemin, J. Lacour, Angew. Chem. Int. Ed. 2021, 60, 8733-8738; f) H. Li, R. Duwald, S. Pascal, S. Voci, C. Besnard, J. Bosson, L. Bouffier, J. Lacour, N. Sojic, Chem. Commun. 2020, 56, 9771-9774; g) R. Duwald, J. Bosson, S. Pascal, S. Grass, F. Zinna, C. Besnard, L. Di Bari, D. Jacquemin, J. Lacour, Chem. Sci. 2020, 11, 1165-1169.
[3] a) O. Viudes, C. Besnard, A. F. Siegle, O. Trapp, T. Bürgi, G. Pescitelli, J. Lacour, J. Am. Chem. Soc. 2025, 147, 21121-21130; b) C. Montagnon, J. R. Bultel, C. Besnard, L. Guénée, J. Lacour, Chem. Eur. J. 2024, e202401522; c) Y. Nikolova, B. Fabri, P. Moneva Lorente, A. Guarnieri-Ibáñez, A. de Aguirre, Y. Soda, G. Pescitelli, F. Zinna, C. Besnard, L. Guénée, D. Moreau, L. Di Bari, E. Bakker, A. I. Poblador-Bahamonde, J. Lacour, Angew. Chem. Int. Ed. 2022, 61, e202210798; d) J. Viñas-Lóbez, G. Levitre, A. De Aguirre, C. Besnard, A. I. Poblador-Bahamonde, J. Lacour, ACS Org. Inorg. Au 2021, 1, 11-17; e) T. Achard, C. Tortoreto, A. I. Poblador-Bahamonde, L. Guénée, T. Bürgi, J. Lacour, Angew. Chem. Int. Ed. 2014, 53, 6140–6144; f) C. Tortoreto, T. Achard, W. Zeghida, M. Austeri, L. Guénée, J. Lacour, Angew. Chem. Int. Ed. 2012, 51, 5847-5851.