Generation of new fluorophore by Click chemistry: synthesis and properties of beta-cyclodextrin substituted by 2-pyridyl triazole

2-Pyridyl triazole substituted P-cyclodextrins, formed by a HUisgen [2+3] cycloaddition reaction between per-(6-azido)-beta-cyclodextrins and 2-ethynylpyridine, exhibited interesting solvent-polarity dependent fluorescence properties and acted as Zn2+ -Sen- sitive fluorogenic chelating agents with a significant fluorescence enhancement and a large red-shift in emissions. No fluorescent emission was observed with phenyl or hydroxymethyl triazole conjugated sugar derivatives.