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Dr Sébastien Gouin is a CNRS Research Director int the "Chimie et Interdisciplinarité, Synthèse, Analyse, Modélisation" CEISAM laboratory (CNRS and Université de Nantes). The main activity of his "Glycochimie et Bioconjugués" research group within the CORAIL team focuses on the development of synthetic glycoconjugates to interact with sugar-recognizing proteins (lectins and glycosidases).
Abstract
Increasing bugs resistances to antibiotics or antifungals is a serious health problem, which is worsening with the constant identification of strains resilient to commonly available chemotherapeutic agents. Our group is interested in developing antagonists of carbohydrate-binding and processing enzymes as “glycotools” to disrupt the attachment of pathogenic bacteria and fungi to host cells. The design of mono- and multivalent glycoconjugates and their in vitro and in vivo potential will be discussed.
Our second research interest focuses in the development of new bioconjugation methods. The chemo-selective modification of native proteins is of particular importance in chemical biology and for the development of therapeutic conjugates. Recently, we developed the first electrochemical method coined eY-click to functionalize tyrosine (Y) residues of proteins in biocompatible media. The click-electrochemistry method was explored for remodeling the surface of therapeutic viruses, gram-/+ bacterial strains, and eukaryotic cell lines.